Journal article
Enhancement of antibody-dependent cellular cytotoxicity and phagocytosis in anti-HIV-1 human-bovine chimeric broadly neutralizing antibodies
JM Edwards, B Heydarchi, G Khoury, NA Salazar-Quiroz, CA Gonelli, B Wines, PM Hogarth, AB Kristensen, MS Parsons, DFJ Purcell
Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2021
DOI: 10.1128/JVI.00219-21
Abstract
No prophylactic vaccine has provided robust protection against human immunodeficiency virus type 1 (HIV-1). Vaccine-induced broadly neutralizing antibodies (bNAbs) have not been achieved in humans and most animals; however, cows vaccinated with HIV-1 envelope trimers produce bNAbs with unusually long third heavy complementarity-determining regions (CDRH3s). Alongside neutralization, Fcmediated effector functions, including antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADP), may be critical for in vivo bNAb antiviral activity. Here, we aimed to augment the Fc-dependent effector functions of a chimeric human-bovine bNAb, NC-Cow1, which binds the CD4 binding site (CD4bs) and..
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Grants
Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by an Australian NHRMC-EU Horizons 2020 grant (APP1115828) , as a partner in the European AIDS Vaccine Initiative 2020 (EAVI 2020) , and a Australian NHMRC Program grant, APP1052979. In addition, grants were received from the Australian Centre for HIV and Hepatitis Virology Research, the Melbourne HIV Cure Consortium, the Victorian Infection and Immunity Network, and the Victorian State Government Technology Voucher Scheme. This research is supported by the National Institutes of Health's Office of the Director, Office of Research Infrastructure Programs, P51OD011132.